Bone Abstracts

Growing body of evidence shows that microRNAs play an important role in regulating bone mass. We investigated the cooperative microRNA-mRNA regulatory mechanism of peak bone mass in inbred strain of mice with different bone density using microarray analysis. Femur and tibia of 12-week old C3H/He (high bone density) and C57BL/6 (low bone density) were harvested to extract total bone RNAs for microarray. A total of 30 miRNAs were differentially expressed between bone tissue of C...

Nutrition is a major modifiable factor that affects bone health. Dietary potassium may act as an alkaline source by neutralizing the acid load and reducing calcium loss from bone.We aimed to evaluate the association between dietary potassium intake and bone mineral density (BMD) in the Korean population. We analyzed data from the Korean National Health and Nutrition Examination Survey (KNHANES) A total of 3135 men aged >50 years and 4052 postmenopaus...

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which functions as bile acid sensor controlling the bile acid homeostasis. We have investigated the role of FXR in regulating bone metabolism in vivo. We have identified expression of FXR in calvaria and bone marrow cells, which was gradually increased during osteoblastic differentiation in vitro. Deletion of FXR in vivo has resulted in significant reduction in bone mineral density by...

Background: Aromatase inhibitors (AIs) increase the risk of fracture in patients with breast cancer. Therefore, we aimed to evaluate the long-term effects of AIs on bone health in postmenopausal women with primary breast cancer.Patients and methods: We performed a retrospective longitudinal observational study in patients with breast cancer who were treated by AIs for ≧3 years (baseline T-score >–2.5). Patients with previous anti-osteoporosis...